Figure 1. The most hydrophobic lipids (triglycerides, cholesteryl esters) form a central droplet-like core, which is surrounded by more polar lipids (phospholipids, free cholesterol) at the water interface. Apolipoproteins are anchored by their more hydrophobic regions, with their more polar regions often exposed to the surface. LCAT, lecithin:cholesterol acyltransferase. Reproduced with permission from Durrington PN. Hyperlipidaemia: Diagnosis and Management. 2nd edition. London: Butterworth-Heinemann; 1995.