Figure 3. An outline of the major metabolic pathways by which chylomicron remnants and low-density lipoprotein (LDL) are formed from chylomicrons and very-low-density lipoprotein (VLDL), respectively, and subsequently catabolised. High-density lipoprotein (HDL) is secreted by the gut and liver and receives additional components during the metabolism of triglyceride-rich lipoproteins. IDL, intermediate-density lipoprotein; apo, apolipoprotein; TG, triglyceride; CE, cholesteryl ester; CETP, cholesteryl ester transfer protein; SR, scavenger receptor; LCAT, lecithin: cholesterol acyltransferase. Adapted with permission from Durrington PN. Hyperlipidaemia: Diagnosis and Management. 2nd edition. London: Butterworth-Heinemann; 1995.